Mouse Tumor Biology Database
NAR Molecular Biology Database Collection entry number 152
Bult, Carol; Krupke, Debra; Begley, Dale; Richardson, Joel; Neuhauser, Steven; Sundberg, John; Eppig, Janan
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
The Mouse Tumor Biology Database (MTB) is a Web-based resource that provides access to information on tumor frequency, genetics, and pathology in genetically defined mice (i.e., transgenics, targeted mutations, and inbred strains). MTB is designed to serve cancer genetics researchers who use the laboratory mouse as a model system for understanding the genetic and molecular basis of human disease processes. The database can be used to answer such queries as 'What tumors are typically observed in the FVB/N strain?', 'What strains of mice have been reported to develop mammary cancers that subsequently metastasize to the lung?', or 'What tumors in mice are associated with mutations in the Trp53 gene?'. The data represented in MTB are obtained from curation of the primary scientific literature and from direct submissions by members of the scientific community. Existing standards for anatomy, tumor names, gene names, and strain names are enforced to facilitate linking information in MTB to other relevant databases and to ensure completeness and accuracy of the results returned in response to user queries. MTB is accessible from the Mouse Genome Informatics (MGI) Web site (http://www.informatics.jax.org). User support is available via email at firstname.lastname@example.org.
The focus of the MTB staff over the past year has been on data acquisition and curation of published research using mouse models to study cancers that are most common in humans (i.e., cancers of the lung, breast, prostate, colon, ovary, bladder, skin, etc.). To give database users an overview of the data content of MTB, a dynamically generated database report is now available from the home page. To enhance access to the cancer genetics literature, MTB users can now query specifically for a list of published review articles on the use of mouse models to study specific human cancers. Reciprocal links were established between MTB and the Mouse Phenome Database (MPD; http://www.jax.org/phenome/). The MPD database contains baseline biological data for over 50 of the most commonly used inbred strains of the laboratory mouse.
The MTB Database has been supported, in part, by the TJL Cancer Core Grant USPHS P30 CA34196.
Category: Human Genes and Diseases
Subcategory: Cancer gene databases
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