The study of lncRNA-disease associations is becoming one of the most important topics of lncRNAs and diseases. For this reason, a high quality lncRNA-disease association database will be helpful in studying the roles of lncRNAs in diseases but is still not available. In this paper, we describe a long noncoding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease.
LncRNADisease database collected and curated ~480 entries of experimentally supported lncRNA-disease associations including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA, and DNA.Moreover, we annotated lncRNA-disease associations with genomic information, sequences, references, and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA-disease associations and integrated the method and the predicted associated diseases of 1, 564 human lncRNAs into the database.
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