Skip Navigation


NAR Molecular Biology Database Collection entry number 318
The UniProt Consortium1,2,34
1 EMBL Outstation - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
2Swiss Institute of Bioinformatics and Department of Structural Biology and Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
3Protein Information Resource, Georgetown University Medical Center, Suite 1200, 3300 Whitehaven Street NW, Washington, DC 20007, USA and Department of Biochemistry, and 4University of Delaware, 15 Innovation Way, Suite 205, Newark, DE 19711, USA

Database Description

The Swiss-Prot, TrEMBL, and PIR protein database activities have united to form the Universal Protein Resource (UniProt), which provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), comprising the manually annotated UniProtKB/Swiss-Prot section and the automatically annotated UniProtKB/TrEMBL section, is the preeminent storehouse of protein annotation. The extensive cross-references, functional and feature annotations, and literature-based evidence attribution enable scientists to analyze proteins and query across databases. The UniProt Reference Clusters (UniRef) speed similarity searches via sequence space compression by merging sequences that are 100% (UniRef100), 90% (UniRef90), or 50% (UniRef50) identical. Finally, the UniProt Archive (UniParc) stores all publicly available protein sequences, containing the history of sequence data with links to the source databases. The UniProt databases continue to grow in size and in availability of information. New download availability includes all major releases of UniProtKB, sequence collections by taxonomic division, and complete proteomes. A bibliography mapping service has been added, and an ID mapping service will be available soon.


UniProt is mainly supported by the National Institutes of Health (NIH) grant 1 U01 HG02712-01. Minor support for the EBI's involvement in UniProt comes from the two European Union contracts BioBabel (QLRT-2000-00981) and TEMBLOR (QLRI-2001-00015) and from the NIH grant 1R01HGO2273-01. Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science. PIR activities are also supported by the National Science Foundation (NSF) grants DBI-0138188 and ITR-0205470.


1. The UniProt Consortium (2012). Reorganizing the protein space at the Universal Protein Resource (UniProt). Nucleic Acids Res. 40: Database issue (in press).

Go to the abstract in the NAR 2014 Database Issue.
Oxford University Press is not responsible for the content of external internet sites