NAR Molecular Biology Database Collection entry number 793
Centre for Arab Genomic Studies, P.O. Box 22252, Dubai, United Arab Emirates
In the Arab World, genetic diseases represent a major public health problem. Several factors contribute to the wide prevalence of genetic disorders in the region including the high rate of consanguinity, social trend to have more children until menopause, selective factors favoring inherited disease characters, and the lack of public awareness towards the early recognition and prevention of inherited disease. Recently, the Centre for Arab Genomic Studies (CAGS) initiated the ambitious project to establish the CTGA (Catalogue of Transmission Genetics in Arabs) database for genetic disorders in Arabs with the aim to enlighten the scientific community and the public on the occurrence of inherited disorders in Arabs and to suggest future investigation strategies. The CTGA database is continuously expanding its coverage since its public release in December 2004 by collecting data from published literature (national and international), hospital records, and personal communications. CTGA currently includes more than 900 records of Mendelian disorders described in Arab populations. Many of these records contain information about rare genetic disorders, mostly autosomal recessive, for which the genetic pathologies have not been characterized yet. Genetic linkage and genotype-phenotype correlation analyses of each of these disorders will surely offer a better understanding of the functions of the human genome. In 2004, the emphasis in the CTGA database was to collect data on the occurrence of genetic disorders in the United Arab Emirates. At present, the database is enlarging its coverage to include detailed information on genetic disorders occurring in other Arab countries.
The Centre for Arab Genomic Studies is a division of H.H. Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences. Funding is provided by Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences. We thank the Executive Committee Members of CAGS and colleagues in the various medical and academic centers who facilitated data collection in the UAE.
Category: Human Genes and Diseases
Subcategory: General polymorphism databases
Go to the abstract in the NAR 2006 Database Issue.
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