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NAR Molecular Biology Database Collection entry number 8
Gribskov, M.1,2, Bier, E.2, Reiter, L.T.2, Chien, S.1,2
1San Diego Supercomputer Center, University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0537
2Department of Biology, University of California, San Diego, 9500 Gilman Dr., La Jolla CA 92093-0349

Database Description

Although many human genes have been associated with disease phenotypes, knowing the mutations in one or several disease genes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic disease. Homophila is an intergenomic resource linking the human and fly genomes in order to provide a tool for planning functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila is a relational database that allows searching based on human disease descriptions, fly phenotypes, human or fly gene names and sequence similarity. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man and the complete Drosophila genomic sequence. Homophila is available at


This work supported in part by the National Institutes of Health through grant through a National Center for Research Resources program grant (P 41 RR08605-06) to the National Biomedical Computation Resource at the San Diego Supercomputer Center.


Reiter, LT; Potocki, L; Chien, S; Gribskov, M; Bier, E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. GENOME RESEARCH, 2001, 11:1114-1125.

Go to the abstract in the NAR 2002 Database Issue.
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