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Virus Variation

NAR Molecular Biology Database Collection entry number 909
J. Rodney Brister, Yiming Bao, Sergey A. Zhdanov, Yuri Ostapchuck, Vyacheslav Chetvernin, Boris Kiryutin, Leonid Zaslavsky, Michael Kimelman and Tatiana A. Tatusova
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

Database Description

The NCBI Influenza Virus Sequence Database ( contains nucleotide sequences, protein sequences and their encoding regions of all influenza viruses in GenBank. The database is updated usually within a day or two after new sequences become available in GenBank. Information for database fields (subtype, segment, host, country, year etc.) are extracted automatically from GenBank records, and examined by NCBI staff. Information not available in GenBank records are obtained from literature or direct contact with sequence submitters, whenever possible. There are 4 major applications of the NCBI Influenza Virus Sequence Database: database browsing and sequence retrieving; complete genome sets finding; multiple sequence alignment; and cluster or phylogenetic tree building. All of these applications start from the database query page with slightly different restrictions for certain applications (e.g. sequences from different segments cannot be mixed for multiple sequence alignment or tree building). For users' convenience, individual interfaces were custom-made for each application. Data in the NCBI Influenza Virus Sequence Database are available for downloading from <


1. Ghedin E, Sengamalay NA, Shumway M, Zaborsky J, Feldblyum T, Subbu V, Spiro DJ, Sitz J, Koo H, Bolotov P, Dernovoy D, Tatusova T, Bao Y, St George K, Taylor J, Lipman DJ, Fraser CM, Taubenberger JK, Salzberg SL. (2005) Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature 437: 1162-1166.

Subcategory: Viral genome databases

Go to the abstract in the NAR 2014 Database Issue.
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