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Editors

SENIOR EDITORS

Alan Fersht

UK

Valerie Daggett

US

CONSULTING EDITOR

Greg Winter

UK

METHODS EDITOR

Arne Skerra

Germany

EDITORIAL BOARD

Neils Andersen

US

Miniprotein design; beta-sheet models; folding dynamics; NMR; structure analysis

Frances Arnold

US

Directed evolution; cytochrome P450; protein design; in vitro selection; enzyme engineering

P Balaram

India

Protein design; de novo peptide design; protein folding; analysis of motifs; disulfide engineering

Lars Baltzer

Sweden

De novo protein design; (protein design); peptide; bioorganic; catalysis; molecular recognition; reactivity

Hagan Bayley

UK

Biosensors; biomolecular materials [fibers, elastomers, adhesives etc.];chemical modification of proteins; membrane proteins; photochemistry; single molecule biology

Hugues Bedouelle

France

Recombinant antibody; aminoacyl-tRNA; synthetase; biosensor; infectious agent; phage display; protein stability; therapeutic protein

Albert Berghuis

Canada

Structural Biology; structural bioinformatics; computational chemistry; enzyme mechanism; enzyme evolution

Alan Berry

UK

Directed evolution; mechanistic enzymology; aldolases; enzyme engineering

Paula Booth

UK

Carl Borrebaeck

Sweden

Immunotherapy; antibody engineering; target discovery; cancer; lymphomas; B cell developmen; microarrays; proteom analysis; allergy

Stephen Bottomley

Australia

Protein folding and misfolding; protein expression; expression systems; protein aggregation; spectroscopy

Andrew Bradbury

US

Phage display; selection systems; antibodies; fluorescent proteins; GFP; cre/lox recombination

Dennis Burton

US

Antibodies; antibody engineering; virus glycoproteins; HIV; prion proteins

Paul Carter

US

Antibodies; in vitro evolution; therapeutic proteins

Ashutosh Chilkoti

US

Protein based polymers; stimuli responsive polypeptides; protein-polymer conjugates

Jason Chin

UK

Fabrizio Chiti

Italy

Protein misfolding; protein aggregation; protein folding; amyloid fibrils; mechanisms of amyloid formation; protein deposition diseases; amyloid diseases

Brian Clark

Denmark

Protein synthesis; proteomics; protein modification; ageing

Jane Clarke

UK

Protein folding; protein stability; protein dynamics; force spectroscopy; AFM; protein elasticity; single molecule studies

Marius Clore

US

NMR spectroscopy; structural biology; protein-protein interactions; protein-nucleic acid interactions; transcriptionfactors; signal transduction; computational chemistry; structure determination methods; structure prediction

Fred Cohen

US

Protein misfolding; prion diseases; heteropolymer design; protein modeling

Matt Cordes

US

Protein folding; protein evolution ; nuclear magnetic resonance ; conformational switching

Mirek Cygler

Canada

Protein structure; enzymatic mechanism; glycosaminoglycan processing enzymes; proteases and esterases; structural genomics

Alan Davidson

Canada

Protein folding; mutagenesis; SH3 domains; folding and sequence conservation

Michael Deem

US

Statistical mechanics; protein evolution; original antigenic sin

William DeGrado

US

Protein design; bioinorganic chemistry; protein folding

Bauke Dijkstra

Netherlands

Protein structure; enzyme mechanisms; protein engineering; crystallography; biophysical techniques

Christopher Dobson

UK

William Eaton

US

Protein dynamics, folding and self-assembly; sickle cell disease

David Eisenberg

US

Amyloid; domain swapping; prion structure; protein interations; functional networks

Edward Eisenstein

US

Jacques Fastrez

Belgium

Directed evolution; selection for catalytic activity; phage display; proteases; lactamases and peptidases

Angelo Fontana

Italy

Protein folding; proteolysis; biospectroscopy; protein chemistry ; mass spectrometry

Assaf Friedler

Israel

peptides; peptide engineering; protein-protein interactions; biophysics; pharmacological chaperones; medicinal chemistry; HIV-1 proteins; cancer

Stefano Gianni

Italy

Protein folding; structural biology; protein-protein interaction; biophysics; kinetics

Adrian Goldman

Finland

Protein structure; x-ray crystallography; enzyme modification; protein evolution

Richard Goldstein

UK

Protein evolution; protein bioinformatics

Andrew Griffiths

UK

Directed evolution; selection; phage display; antibody selection; enzyme evolution

Angela Gronenborn

US

NMR spectroscopy; protein structure and dynamics; folding and assembly; protein interactions; molecular recognition and signalling

Bernd Gutte

Switzerland

De novo design of functional peptides; protein folding; retro-proteins; phage display of peptide libraries

Michael Hecht

US

Protein design; combinatorial methods; library design; mutagenesis; binary patterning; protein expression

Don Hilvert

Switzerland

Phil Holliger

UK

Directed evolution; repertoire selection; polymerases; replication; nucleotide chemistry

Hennie Hoogenboom

Netherlands

Antibody engineering; protein expression; display methods; molecular evolution; cancer immunotherapy

Nick Hoogenraad

Australia

Molecular chaperones; protein folding; stress response; protein targeting; mitochondrial biogenesis

Amnon Horovitz

Israel

Chaperonins; allostery; mutant cycles; protein folding

Arthur Horwich

US

Molecular chaperones; chaperonins; GroEL; folding in vivo; amyloids; TTR

Peter Hudson

Australia

Protein structure and design; directed molecular evolution; display and selection technologies; protein arrays and biosensors

James Huston

US

Antibody engineering, recombinant fusion proteins and linkers, engineered bispecifics, immunotargeting, antibody therapeutic and imaging agents, intracellular antibody therapy.

Taiji Imoto

Japan

Stabilization; folding; reaction mechanisms; chemical modification; antigenicity

Leo James

UK

Immunology; structural biology/x-ray crystallography; kinetics; biophysics; protein-protein recognition

Dick Janssen

Netherlands

hydrolases; enzyme kinetics; biocatalysis; dehalogenases

Laurent Jespers

UK

Phage display; antibody engineering; molecular evolution; domain antibody

Jeff Kelly

US

Thomas Kiefhaber

Switzerland

Protein folding; protein stability; reaction kinetics; protein dynamics

Andreas Kungl

Austria

Protein engineering; fluorescence; circular dichroism; microcalorimetry; proteomics; molecular dynamics; chemokines

Robin Leatherbarrow

UK

Peptide chemistry; peptide synthesis; protease; protease inhibitor; protein; NMR; enzyme kinetics; enzyme inhibition; molecular interactions

Bengt Mannervik

Sweden

Glutathione; combinatorial protein chemistry; directed evolution; phage display; protein redesign

Susan Marqusee

US

James Marks

US

Andreas Matouschek

US

Protein folding and unfolding; protein degradation; ATP-dependent proteases; protein translocation across membranes; mechanism of protein machines

Brian Matthews

US

Protein crystallography; protein stability; protein design.

Stephen Mayo

US

Protein design; protein stability; combinatorial optimization; molecular modeling; force fields

Liz Meiering

Canada

Protein folding; protein stability; protein misfolding and aggregation

Vadim Mesyanzhinov

Russia

Protein design; foldon; enzybiotics; virus; bacteriophage

Andrew Miranker

US

Protein folding; spectroscopy; amyloid; protein-protein interactions; complex assembly

Kosuke Morikawa

Japan

Protein crystallography; DNA binding protein; ligand receptor interaction

Regina Murphy

US

Protein/Peptide misfolding and aggregation; kinetics of amyloidogenesis; light scattering

Haruki Nakamura

Japan

Structural bioinformatics; protein and proteome databases; structural proteomics; molecular simulation; protein folding

Dario Neri

Switzerland

Therapeutic antibodies; protein libraries and selection methodologies; chelate effect and high-affinity binding; protein-based in vivo targeting, with special emphasis on angiogenesis-related diseases

Feng Ni

Canada

Polypeptide design; signaling protein interactions; binding allostery; instrinsically-unstructured proteins (IUPs); NMR; blood coagulation and antithrombotics

Robin Offord

Switzerland

Chemically synthesized proteins; semisynthetic proteins and peptides; chemokines; HIV receptor antagonists

Mikael Oliveberg

Sweden

David Ollis

Australia

X-ray crystallography; protein structure; function and engineering; directed evolution; enzyme mechanism

Christine Orengo

UK

Protein family classification and analysis, structural genomics

Jane Osbourn

UK

Antibody engineering; phage display; ribosome display; selection technology

Hartmut Oschkinat

Germany

Daniel Otzen

Denmark

Protein folding kinetics; protein stability; membrane protein biophysics; protein fibrillation; surfactants

Evamaria Petersen

Denmark

Protein engineering; molecular directed evolution; lipase; lipid binding proteins

Andreas Plueckthun

Switzerland

Directed evolution; display and selection technologies; ligand binding; protein stability; antibody engineering; protein design

Flemming Poulsen

Denmark

Protein struture; protein folding; protein dynamics protein stability and NMR spectroscopy

Sheena Radford

UK

Folding; misfolding; amyloid; single molecules; AFM

Ron Raines

US

Chemical biology; protein chemistry; enzymology

Daniel Raleigh

US

Amyloid formation and protein aggregation; protein design; protein stability and thermodynamics; NMR

Anthony Rees

Sweden

Antibody modeling; antibody mimetics; artificial receptors

Lynne Regan

US

Protein design; folding; stability; helical proteins; protein-metal interactions; protein-protein interaction; protein-RNA interactions

Heinrich Roder

USA

Protein folding; kinetics; folding intermediates; rapid mixing; NMR; hydrogen exchange

Peter Roepstorff

Denmark

Mass spectrometry; proteomics; post translational modifications; protein interaction

Steven Russell

US

Virotherapy; gene therapy; virus display; targeting; membrane fusion

Andrej Sali

US

Protein structure analysis and modeling; protein assembly analysis and modeling

Mark Sansom

UK

Membrane proteins; ion channels; molecular dynamics; homology modelling

Jeffery G. Saven

US

Harold Scheraga

US

Protein folding; physical chemistry; statistical mechanics; global optimization

Gideon Schreiber

Israel

Protein-protein interaction; binding kinetics; proteomics; protein design; interferon; cooperativity

Klaus Schulten

US

Computational biology; membrane proteins; mechanical proteins; photosynthetic apparatus; nanosystem bioengineering;

Luis Serrano

Germany

Folding; Design; Biocomputing; Amyloid; Structure analysis

P C Shaw

Hong Kong

Molecular biology & protein engineering; protein-protein interaction; ribsome inactivating protein; N-glycosidase; DNA methylase

Arne Skerra

Germany

Rational design; combinatorial selection; antibody engineering; binding proteins; protein crystallography

Dieter Soll

US

Aminoacyl-tRNA synthetases; RNA modification enzymes; RNA; protein interactions

Tobin Sosnick

US

Protein folding; RNA folding; kinetics; hydrogen exchange; small-angle scattering

Patrick Stayton

US

Biohybrid materials; smart protein conjugates; biomineralization

Michael Sternberg

UK

Bioinformatics; protein modelling

Robert Stroud

US

Protein crystallography especially applied to membrane channels and receptors and to drug design aimed at therapeutically important targets

Joel Sussman

Israel

Protein crystallography; bioinformatics; neurobiology; intrinsically unfolded proteins; structural proteomics; halophilic/halotolerant proteins; acetylcholinesterase/butyrylcholinesterase

Lukas Tamm

US

Dan Tawfik

Israel

Enzyme evolution; directed evolution; enzyme mechanisms; protein conformation; antibodies

David Thirumalai

US

Computational and theoretical biophysics; protein folding; protein aggregation; chaperone-mediated folding; single molecule studies

Hans Thøgersen

Denmark

Antibody mimics; protein tinkering; protein-drug design; refolding; large-scale protein processing

Janet Thornton

UK

Computational biology; bioinformatics; structural biology; genomics

Bruce Tidor

US

Computational biology; protein and ligand design; electrostatic interactions; molecular dynamics; protein-DNA interactions; systems biology

Peter Tieleman

Canada

Expertise terms: membrane proteins, protein modeling, biomolecular simulation, membrane biophysics

Jayant Udgaonkar

India

Mathias Uhlen

Sweden

Proteomics; combinatorial selection; affinity purification; expression profiling

Rebecca Wade

Germany

Computational biology; molecular recognition; molecular dynamics; protein and ligand design; molecular simulation

Sally Ward

USA

Rik Wierenga

Finland

Protein crystallography; protein engineering; TIM; CoA; enzymology

Tony Wilkinson

UK

Protein structure; enzyme mechanisms; protein engineering; crystallography; expression systems

Roger Williams

UK

Protein structure; signal transduction; protein/lipid interactions; phosphoinositide signalling

Stephen Withers

Canada

Enzyme mechanisms; glycosyl transfer; glycosidase; carbohydrates

Kambo Wong

Hong Kong

NMR; protein crystallography; protein stability; protein engineering

Dek Woolfson

UK

Structural studies of peptides and proteins; rational protein design; combinatorial design and selection; nanobiotechnology

Anna Wu

US

Recombinant antibody fragments; antibody fusion proteins; molecular imaging; pharmacokinetics; bioconjugation of nanomaterials

Todd Yeates

US

Protein structure and design; x-ray crystallography; symmetry and self-assembly; protein topology and knots, algorithms

Mark Zoller

US

Molecular biology and protein engineering; phage display; protein kinases; GPCRs and ion channels involved in taste and smell