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About the Journal

The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish premier, peer-reviewed, hypothesis-driven, original research articles in all areas of toxicology. Toxicological Sciences ScholarOne Manuscripts, our online submission system, is located at ScholarOne Manuscripts facilitates convenient uploading of original and revised manuscripts, as well as online reviewing and intercommunication between authors, editors, and reviewers.

Presenting novel and impactful articles on:

  • Structural, functional, biochemical and molecular effects of toxic agents
  • Investigations that address mechanisms of toxicity
  • Relevant translational data for human health assessment
  • Statistical or mechanism-based approaches to risk assessment
  • New methods in toxicology

Featured Sections:

Original Research Articles

Timely Reviews

Forum Articles on policy or research issues


Letters to the Editor

Supplementary Data

Research Areas:

Toxicological Sciences features premier articles broadly covering many aspects of toxic responses, and section categories are provided to facilitate the organization and reading of the journal. Authors select the category for original research articles during the submission process, although categories may be revised prior to publication. The section headings with brief, general descriptions are as follows:

  • Biomarkers of Toxicity--identification, validation, and utilization of biomarkers of exposure or biomarkers of toxicity. May be applied to studies in laboratory animals or humans.
  • Biotransformation and Toxicokinetics--xenobiotic disposition, regulation of enzymes involved in metabolism and fate, role of metabolism in toxic mechanisms, and development of pharmaco/toxicokinetic models.
  • Carcinogenicity--mechanisms of chemical carcinogenesis, studies that explore the human relevance of animal carcinogenicity data, and human epidemiological data that may inform human cancer risk assessment.
  • Endocrine Toxicology--effects of toxicants on endocrine organs (including cell systems) and/or endocrine function.
  • Environmental Toxicology--effects of chemicals or other agents on environmental species including fish, birds, or terrestrial species, with emphasis on mechanism of action and assessment of species differences in sensitivity.
  • Genetic Toxicology--effects of chemicals on DNA, including replication and repair, evaluation of human relevance of genetic toxicology data, and important advancements and/or improvements in genetic toxicology methods.
  • Immunotoxicology--effects of toxicants on cells and organs of the immune system and/or their function.
  • In Vitro Methods and Alternatives to Animals--studies conducted in cell culture or other in vitro systems to evaluate mechanisms of toxicity and/or relevance to humans. Includes methods developed specifically to reduce the use of animals in toxicological research.
  • Molecular Toxicology--studies emphasizing the role of a specific gene, gene family, and/or genetic polymorphism in toxic responses. May include adverse cellular effects mediated through signaling mechanisms.
  • Nanotoxicology--studies on the toxic responses observed with nano materials in any test system.
  • Neurotoxicology--effects of toxicants on the peripheral or central nervous system and/or nervous system function.
  • Reproductive and Developmental Toxicology--effects of toxicants on reproductive function and developing offspring.
  • Respiratory Toxicology--effects of toxicants on the respiratory tree and/or pulmonary and respiratory function.
  • Risk Assessment--studies that develop strategies or provide relevant new toxicological data for developing human risk assessments, including hazard characterization, exposure assessment, and mode of action information.
  • Safety Evaluation--studies that identify toxicological hazards of chemicals, drugs, or other agents or to develop methods that can be used for hazard identification.
  • Stem Cells and Stem Cell Derived Tissues--studies all types of stem cell models including embryonic, fetal, progenitor, mesenchymal, epithelial, induced pluripotent and tissues derived from pluripotent stem cells as they relate to the general science of toxicology.
  • Systems Toxicology--effects of toxicants on major organ systems not covered by other section headings (e.g, liver, kidney). Includes global analyses such as metabonomics, proteomics, and toxicogenomics.
  • Translational Research in Toxicology--data obtained in human subjects and applied to translation and/or interpretation of toxicological findings.

General Guidelines:

Research articles. For complete preparation and submission instructions, see Information for Authors on the ToxSci home page. You may also wish to consult the Conflict of Interest Guidelines.

Review articles. Review articles provide a focused, current discussion of a scholarly topic relevant to toxicologists. Articles should be limited to no more than fifteen pages or approximately 15,000 words. We encourage the use of supplementary data when feasible to enhance the content of the review. Proposals for reviews should be submitted to the editor prior to preparation, and all articles will be subject to Editorial Board approval prior to publication.

Forum. The Forum section includes discussions and commentaries providing an interface between toxicology and public policy. Commentaries should briefly discuss a sharply focused topic of recent relevant policy decisions or experimental research. These articles must also provide a critical and balanced view of the issue or research area. Articles summarizing the outcome of workshop or other focused meetings will also be considered in the Forum section of the journal. Workshops dealing with issues that represent timely and relevant topics in toxicology are preferred. Organizers are encouraged to contact the Editor prior to the meeting to discuss the interest and appropriateness of the intended article for Toxicological Sciences, and since timely reporting is essential, reports should be submitted for consideration for publication within 4 months of the date of the meeting. Workshop reports should not simply detail the points of discussion but rather, they should be organized to clearly and succinctly state the issue and the objective(s) of the meeting along with the salient aspects relating to the important outcomes and recommendations made from the meeting. All Forum articles should also be limited to no more than 5000 words. The use of supplementary data is encouraged to keep the printed version of the meeting report within the recommended limits on length.

Proposals for forum articles should be submitted to the editor prior to preparation, and all articles will be subject to Editorial Board approval prior to publication.

Editorials. Commentaries and perspectives on subjects broadly relevant to toxicity, human or environmental health, or biomedical research are welcome. These brief articles should not exceed 700 words. Proposals for Editorials should be submitted to the Editor prior to preparation. Editorials will be subject to Editorial Board approval prior to publication.

Letters to the Editor. Letters to the Editor regarding published articles should be submitted within 2 months of mailing of the journal. Letters should have a descriptive title and the body of any letter must not exceed 1000 words, including references. References may be published as Supplementary Data. Letters submitted outside these parameters will be returned with a revision request to conform to these requirements. Introduction of new data will not be permitted. Letters will be peer-reviewed for factual accuracy and originality. Unsubstantiated claims or opinions will not be permitted. Each letter will be submitted to the author of the original paper so that any reply may be published simultaneously with the letter. Final publication of either letter is at the discretion of the Editor.

Supplementary Data. Supplementary Data is supporting material that cannot be included in the printed version for reasons of space and that is not essential for inclusion in the full text of the manuscript but would nevertheless benefit the reader. It should not be essential to understanding the conclusions of the paper but should contain data that is additional or complementary and directly relevant to the article content. For more detailed information, please see Supplementary Data Guidelines.

Please contact the Editorial Office (302-326-9313) with any specific questions.


Advanced Access articles are initially published in their 'Accepted Manuscript' form as soon as possible post acceptance. Subsequently, a copyedited, typeset, corrected version of the 'Corrected Proof' is also published on the Advanced Access page. More information, including how to cite Advance Access papers, can be found on the Advance Access Page. Advance Access papers are fully integrated into the journal's online system. Abstracts and titles are searchable and accessible within the journal's Web pages, the entire HighWire archive, and PubMed.


YearImpact FactorSi: Toxicology
20124.3288 out of 85
20114.6529 out of 83
20105.0933 out of 83
20094.8144 out of 77
20084.4435 out of 75
20073.8147 out of 73
20063.5989 out of 76

This information is taken from the Journal Citation Reports, published annually as part of the Science Citation Index by ISI.


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