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About the Journal


The mission of Toxicological Sciences is to publish the most influential research in the field of toxicology.

About the Journal

The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish the most influential research in the field of toxicology. The primary focus is on original and hypothesis-driven research articles, but the journal does publish timely reviews, as well as forum articles and editorials that address important topics in the field.

Examples of the types of research articles published include:

  • Structural, functional, biochemical, and molecular effects of toxic agents
  • Studies that address mechanisms of toxicity
  • Relevant translational data for human health assessment
  • Statistical or mechanism-based approaches to risk assessment
  • Novel methods or approaches to studying toxicology

Featured Sections:

In the past, Toxicological Sciences utilized subheadings to identify the area of research for each manuscript. Owing to the ever-increasing level of collaboration and interdisciplinary research, these categories have become obsolete. The Journal now publishes all articles without the use of subheadings. The journal is working on a system that can identity multiple areas of research for each paper and hope to introduce that in the near future.

Toxicological Sciences uses ScholarOne Manuscripts for online submission located at This system facilitates convenient uploading of original and revised manuscripts, as well as online reviewing and communication among authors, editors, and reviewers.

For General Guidelines, click here.

Research articles. For complete preparation and submission instructions, see Information for Authors on the ToxSci home page. You may also wish to consult the Conflict of Interest Guidelines.

Contemporary Reviews. Toxicological Sciences publishes Contemporary Reviews in Toxicology (3,500 word limit), which provide expert analysis of important and emerging areas in the field of toxicology. Contemporary Reviews will not be posted online ahead of print in Advance Access; rather, they will publish with the monthly issue of the journal. All Contemporary Reviews require prior approval by the editor. A Review Proposal "Manuscript Type" is available on the manuscript submission site for authors to suggest a review on a particular topic. You will be asked to provide the basics of Title, Abstract, three keywords, Authors, etc., as well as the following:

A compelling explanation of the need and timeliness of the Review (<500 words).
Estimated Submission Date.
A list of 10-15 key references within the previous 3-5 years.

Title. Titles should be relatively brief (fewer than 12 words) and emphasize the importance of the topic to the field of toxicology.

Authors. No more than 4 authors are permitted except with prior approval by the editor. Each author must make substantial contributions and take responsibility for all content.

Abstract (150-250 words). The abstract should explain why the review topic is important to the field of toxicology, highlight the major recent findings in the field, and provide suggestions for future research.

Text (<3,500 words). The body of the manuscript should be prepared in a way that a non-specialist can understand the importance of the topic. An example target audience would be doctoral students in toxicology, environmental health, or biochemistry. The literature should be reviewed and synthesized to emphasize the key findings and the emerging trends. Authors should provide a balanced examination of the subject matter and reserve opinions to the Future Directions section.

Future Directions (<500 words of the 3,500 total). Authors should be experts in the topic area and as such it is appropriate and encouraged for the author(s) to provide her or his opinion on the topic in this section.

Figures, illustrations, and tables. Authors are expected to provide 2-4 summary figures, diagrams, or tables to help convey the key messages in the manuscript. Text boxes can be used to highlight important aspects of the topic.

References (~75). Contemporary Reviews are not meant to be exhaustive. References should be focused on more recent literature, such that a substantial portion of the references come from the past 5 years.

Forum. The Forum section includes discussions and commentaries providing an interface between toxicology and public policy. Commentaries should briefly discuss a sharply focused topic of recent relevant policy decisions or experimental research. These articles must also provide a critical and balanced view of the issue or research area. It is expected that timely meetings and workshops will result in topics suitable for Forum articles. However, Toxicological Sciences does not publish meeting reports per se. Forum articles must be about the topic of interest in the field and not a particular meeting. Authors are encouraged to submit a Forum Proposal "Manuscript Type" via the manuscript submission site prior to article submission. Forum articles are limited to 5,000 words. The use of supplementary data is encouraged to keep the printed version of the article within the recommended limits on length. Forum articles will not be posted on Advance Access; rather, they will publish within the monthly issue of the journal.

Editorials. Commentaries and perspectives on subjects broadly relevant to toxicity, human or environmental health, or biomedical research are welcome. These brief articles should not exceed 700 words. Proposals for Editorials should be submitted to the Editor prior to preparation. Editorials will be subject to Editorial Board approval prior to publication.

Letters to the Editor. Letters to the Editor regarding published articles should be submitted within 2 months of mailing of the journal. Letters should have a descriptive title and the body of any letter must not exceed 1000 words, including references. References may be published as Supplementary Data. Letters submitted outside these parameters will be returned with a revision request to conform to these requirements. Letters will be peer-reviewed for factual accuracy and originality. Unsubstantiated claims or opinions will not be permitted. Each letter will be submitted to the author of the original paper so that any reply may be published simultaneously with the letter. Final publication of either letter is at the discretion of the Editor.

Supplementary Data. Supplementary Data is supporting material that cannot be included in the printed version for reasons of space and that is not essential for inclusion in the full text of the manuscript but would nevertheless benefit the reader. It should not be essential to understanding the conclusions of the paper but should contain data that is additional or complementary and directly relevant to the article content. For more detailed information, please see Supplementary Data Guidelines.

Please contact the Editorial Office (302-326-9313) with any specific questions.


Advance Access articles are initially published in their "Accepted Manuscript" form as soon as possible post-acceptance. Subsequently, a copyedited, typeset, corrected version of the "Corrected Proof" is also published on the Advance Access page. More information, including how to cite Advance Access papers, can be found on the Advance Access page. Advance Access papers are fully integrated into the journal's online system. Abstracts and titles are searchable and accessible within the journal's Web pages, the entire HighWire archive, and PubMed.


YearImpact FactorSi: Toxicology
20153.88011 out of 89
20143.85411 out of 87
20134.47810 out of 87
20124.3288 out of 85
20114.6529 out of 83
20105.0933 out of 83
20094.8144 out of 77
20084.4435 out of 75
20073.8147 out of 73
20063.5989 out of 76

This information is taken from the Journal Citation Reports, published annually as part of the Science Citation Index by ISI.


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